Effects of Three Types of Japanese Honey on Full-Thickness Wound in Mice

Figure 3

Japanese honey inhibits reepithelialization but increases vascularization. Note the necrotic tissue (*) covering wound surfaces and wound edges (arrows) in the Acacia honey (a), Buckwheat flour honey (b), and Chinese milk vetch honey (c) groups on day 7. This necrotic tissue appears to prevent the migration of epithelium on the wound surface. New epithelium is rapidly formed in the hydrocolloid dressing group (d). There are many large blood vessels in granulation tissue in the Japanese honey groups (e–g) compared with the case in the hydrocolloid dressing group (h). Squares in (a–d) are enlarged into (e–h). D: dermis, E: epidermis, G: granulation tissue, B: blood vessel. Solid line indicates the boundary between normal skin and wound.