Effects of Three Types of Japanese Honey on Full-Thickness Wound in Mice

Table 8

Differentiation between previous studies and present study in wound healing.

Parameter/honey	Previous studies; (Various honeys)	Present study; (Japanese honey)
Edema	Reduced [9, 12, 14, 20]	Not clear (macroscopic)
Debridement	Rapid autolytic [12] and less necrosis [20]	No
Wound area	Decreased [3–5, 21]	Decreased
Inflammation	Increased neutrophils [3, 11] and macrophages [4]; Decreased IL- 6 [5, 8], inflammatory cell number [16], and TNF-α [8]	Decreased macrophages in the inflammatory phase
Reepithelialization	Promoted [4, 7, 9, 12, 14, 20, 21]	Inhibited
Angiogenesis	Stimulated [4, 12, 14]	Stimulated
Contraction	Increased [7, 20, 21]	No increase
Collagen	Increased [4, 7, 9, 21]	No increase