NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
Figure 4
The BBB penetration assay of BMX. Chromatograms of plasma sample from (A) blank plasma; (B) blank plasma spiked with BMX (1 μg/mL, internal standard) and honokiol (10 μg/mL, internal standard); (C) plasma sample from rat plasma 15 min after honokiol (10 mg/kg, positive control, i.v.) and BMX (10 mg/kg, i.v.) administration. 1: honokiol; 2: BMX (a). Chromatograms of brain sample from (A) blank brain tissue; (B) blank brain spiked with BMX (1 μg/mL, internal standard) and honokiol (10 μg/mL, internal standard); (C) brain sample from the rat 15 min after honokiol (10 mg/kg, positive control, i.v.) and BMX (10 mg/kg, i.v.) administration. 1: honokiol; 2: BMX (b). Brain distribution profiles (c) and plasma concentration of BMX (d) 15 min after BMX (10 mg/kg, i.v.) was administered.
