NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
Effects of SAHA and BMX on passive one-way inhibitory avoidance learning in rats. Control, SAHA-, and BMX-injected rats were subjected to passive one-way inhibitory avoidance learning. Retention time in an illuminated compartment before footshock did not show any difference (a). Retention time in an illuminated compartment 1 day and 7 days after footshock was recorded (b). After the experiment, the amygdala was dissected for AcH4K12 western blotting. A representative gel pattern and quantitative analysis of AcH4K12 and the H4 level in the amygdala at 7 days after footshock (c). The HDAC8 activity in the amygdala 7 days after footshock was analyzed (d). The data are the mean ± SEM. *, in the comparison of the control group; #, in the comparison between groups. ; **. One-way ANOVA followed by Newman-Keuls comparisons.