Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 1

Research Article

NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats

Table 1

The inhibition assay of HDACs activities by NBM-T-L-BMX-OS01 (BMX) and trichostatin A (TSA).

HDACs
(EC50, M)
   HDACis
NBM-T-L-BMX-OS01
(BMX)
Trichostatin A
(TSA)

HDAC13.37 × 10−9
HDAC27.14 × 10−9
HDAC32.73 × 10−55.55 × 10−9
HDAC49.51 × 10−8
HDAC56.99 × 10−9
HDAC69.96 × 10−10
HDAC72.46 × 10−8
HDAC88.31 × 10−71.31 × 10−7
HDAC91.39 × 10−8
HDAC101.14 × 10−8
HDAC116.15 × 10−9