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Evidence-Based Complementary and Alternative Medicine

Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 1

Research Article

NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats

Table 1

The inhibition assay of HDACs activities by NBM-T-L-BMX-OS01 (BMX) and trichostatin A (TSA).
HDACs
(EC50, M)		   HDACis
NBM-T-L-BMX-OS01
(BMX)		Trichostatin A
(TSA)
HDAC1—3.37 × 10−9
HDAC2—7.14 × 10−9
HDAC32.73 × 10−55.55 × 10−9
HDAC4—9.51 × 10−8
HDAC5—6.99 × 10−9
HDAC6—9.96 × 10−10
HDAC7—2.46 × 10−8
HDAC88.31 × 10−71.31 × 10−7
HDAC9—1.39 × 10−8
HDAC10—1.14 × 10−8
HDAC11—6.15 × 10−9