Research Article
NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
Table 1
The inhibition assay of HDACs activities by NBM-T-L-BMX-OS01 (BMX) and trichostatin A (TSA).
|
HDACs
(EC50, M) | HDACis | NBM-T-L-BMX-OS01
(BMX) | Trichostatin A
(TSA) |
| | HDAC1 | — | 3.37 × 10−9 | | HDAC2 | — | 7.14 × 10−9 | | HDAC3 | 2.73 × 10−5 | 5.55 × 10−9 | | HDAC4 | — | 9.51 × 10−8 | | HDAC5 | — | 6.99 × 10−9 | | HDAC6 | — | 9.96 × 10−10 | | HDAC7 | — | 2.46 × 10−8 | | HDAC8 | 8.31 × 10−7 | 1.31 × 10−7 | | HDAC9 | — | 1.39 × 10−8 | | HDAC10 | — | 1.14 × 10−8 | | HDAC11 | — | 6.15 × 10−9 |
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