Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II

<table>RWPs treatment prevents the doxorubicin-induced impaired expression levels of SK<sub>Ca</sub>, IK<sub>Ca</sub>, and Cx40 in the mesenteric artery. The expression levels of  SK<sub>Ca</sub>, IK<sub>Ca</sub>, and Cx40 were determined using purified polyclonal antibodies and a fluorescence-tagged secondary antibody by confocal microscopy. Left panels show representative immunofluorescent staining, and right panels show corresponding cumulative data. Results are shown as mean ± SEM of 4 different rats. <svg height="13.95" id="M10" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> indicates a significant effect versus control rats, and <svg height="15.775" id="M11" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus doxorubicin-treated rats.</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II 

Figure 2 | Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II 