Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II

<table>RWPs treatment prevents the doxorubicin-induced expression levels of angiotensin II and AT1 receptors in the mesenteric artery. The expression levels of angiotensin II (Ang II) and AT1 receptors were determined by immunofluorescence. Left panels show representative immunofluorescent staining, and right panels show corresponding cumulative data. Results are shown as mean ± SEM of 4 different rats. <svg height="13.95" id="M15" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> indicates a significant effect versus control rats, and <svg height="15.775" id="M16" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus doxorubicin-treated rats.</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II 

Figure 5 | Grape-Derived Polyphenols Prevent Doxorubicin-Induced Blunted EDH-Mediated Relaxations in the Rat Mesenteric Artery: Role of ROS and Angiotensin II 