The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity

Figure 1

Intake of GE increases the (a) lifespan and (b-i) locomotor activity of Aβ-expressing Drosophila. The lifespan of Aβ42 group (squares in red) is shorter than the control group (circles in blue), while GE (asterisks and triangles in purple) or donepezil (triangles in green) treatments delay the mortality of the Drosophila. (b-ii) is an amplification of the region from days 12 to 23 showing the differences among the Aβ42 group and the treatment groups. The percentage of Drosophila climbing up 8 cm in 10 seconds was increased by GE or donepezil treatments when compared with Aβ42 group. Results are the means ± SEM from five independent crosses. ^###𝑃<0.001 relative to control; *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 relative to Aβ42 Drosophila by one-way ANOVA for locomotor activity. Log-Rank analysis and chi-square comparison were applied to the survival data and 𝑃<0.001 was obtained when comparing Aβ42 Drosophila and Donepezil 10 μmol/g or GE 1 mg/g or 5 mg/g treated ones (𝑛=150).