Metabolic Profiles Distinguish Non-Dampness-Phlegm and Dampness-Phlegm Patterns among Korean Patients with Acute Cerebral Infarction

Table 5

Identification and quantification of metabolites in human plasma using UHPLC-MS and electrospray ionization in negative-ion mode.

Retention; time (min)	Common name	Formula of; [M−H]^−	Measured mass; (m/z)	Theoretical mass; (m/z)	Mass error; (Da)	Non-DP	DP	𝑃
0.64	unknown		291.08			122.96 ± 70.25^a	136.14 ± 107.74	0.869
17.10	LPE(22:6)	C27H43NO7P^−	524.27	524.28	<0.01	65.99 ± 30.35	61.52 ± 25.40	0.419
17.17	LPE(20:4)	C25H43NO7P^−	500.27	500.27	<0.01	45.65 ± 20.26	40.26 ± 17.24	0.065
17.23	LPE(18:2)	C23H43NO7P^−	476.27	476.28	<0.01	70.53 ± 34.49	65.03 ± 35.97	0.289
17.69	LPE(16:0)	C21H43NO7P^−	452.27	452.28	<0.01	48.60 ± 17.28	46.68 ± 18.35	0.258
17.88	LPE(18:1)	C23H45NO7P^−	478.29	478.29	<0.01	27.78 ± 18.78	24.01 ± 12.01	0.409
18.32	Eicosapentaenoic acid (C20:5)	C20H29O2^−	301.21	301.22	<0.01	47.59 ± 31.47	48.31 ± 27.00	0.520
18.37	Linolenic acid (C18:3)	C18H29O2^−	277.21	277.22	<0.01	58.12 ± 50.50	64.84 ± 64.66	0.495
18.64	Docosahexaenoic acid (C22:6)	C22H31O2^−	327.23	327.23	<0.01	268.96 ± 121.50	294.55 ± 116.64	0.093
18.68	Free fatty acid (C16:1)	C16H29O2^−	253.21	253.22	<0.01	83.04 ± 78.33	74.83 ± 63.94	0.901
18.77	Arachidonic acid (C20:4)	C20H31O2^−	303.23	303.23	<0.01	161.10 ± 72.52	149.19 ± 77.86	0.306
18.86	Linoleic acid (C18:2)	C18H31O2^−	279.23	279.23	<0.01	276.78 ± 191.57	279.87 ± 161.58	0.635
18.93	Docosapentaenoic acid (C22:5)	C22H33O2^−	329.25	329.25	<0.01	32.17 ± 23.16	31.04 ± 18.84	0.749
19.04	Free fatty acid (C20:3)	C20H33O2^−	305.25	305.25	<0.01	29.70 ± 19.08	29.47 ± 22.32	0.612
19.18	DG(30:1)	C33H61O5^−	537.41	537.45	−0.04	17.87 ± 9.91	19.65 ± 9.45	0.176
19.27	Palmitic acid (C16:0)	C16H31O2^−	255.23	255.23	<0.01	218.29 ± 140.27	209.29 ± 147.29	0.626
19.32	DG(30:0)	C33H63O5^−	539.42	539.46	−0.04	11.81 ± 7.63	15.08 ± 16.86	0.440
19.36	Oleic acid (C18:1)	C18H33O2^−	281.25	281.25	<0.01	402.57 ± 311.69	378.81 ± 270.00	0.875
19.55	unknown		393.27			63.50 ± 20.78	65.85 ± 22.13	0.641
19.57	MG(22:5)	C25H39O4^−	403.30	403.28	+0.02	69.14 ± 27.41	67.50 ± 31.95	0.405
19.62	Free fatty acid (C17:0)	C17H33O2^−	269.24	269.25	−0.01	20.24 ± 13.09	21.04 ± 14.72	0.862
19.86	unknown		364.49			54.03 ± 18.02	49.21 ± 15.44	0.054
19.89	Stearic acid (C18:0)	C18H35O2^−	283.261	283.264	−0.003	243.29 ± 118.20	220.01 ± 101.87	0.212

aData are presented as mean ± SD. The 𝑃 value was calculated by Mann-Whitney 𝑈-test. LPE: lysophosphatidylethanolamine; DG: diacylglycerol, MG: monoacylglycerol; PE: phosphatidylethanolamine.