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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 527163, 8 pages
http://dx.doi.org/10.1155/2013/527163
Research Article

Complementary and Alternative Medicine: A Survey of Its Use in Pediatric Oncology

1Department of Pediatrics, University of Calgary, Calgary, AB, Canada T2N 4N1
2CARE Program, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada T5K 0L4
3Palladian Health, West Seneca, NY 14224, USA
4Departments of Pediatrics, and of Epidemiology & Community Medicine, University of Ottawa, Ottawa, ON, Canada K1N 6N5
5Canadian Agency for Drugs and Technologies in Health, Ottawa, ON, Canada K1S 5S8
6Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2R3
7Division of Pediatric Medicine, Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada K1N 6N5
8Children's Hospital of Eastern Ontario, Ottawa, ON, Canada K1H 8L1
9Department of Pediatrics, Faculty of Medicine & Dentistry and School of Public Health, University of Alberta, 8B19-11111 Jasper Ave, Edmonton General Hospital, Edmonton, AB, Canada T5K 0L4

Received 11 June 2013; Revised 20 September 2013; Accepted 23 September 2013

Academic Editor: Holger Cramer

Copyright © 2013 Rafiaa Valji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. National Center for Complementary and Alternative Medicine, “What is complementary and alternative medicine?” 2013, http://nccam.nih.gov/health/whatiscam.
  2. S. Braganza, P. O. Ozuah, and I. Sharif, “The use of complementary therapies in inner-city asthmatic children,” Journal of Asthma, vol. 40, no. 7, pp. 823–827, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Dinkevich, P. Sass, L. Pereira et al., “Complementary and alternative medicine use by African-American and Caribbean-American children with asthma,” Pediatric Research, vol. 53, article 188A, 2003. View at Google Scholar
  4. M. Reznik, P. O. Ozuah, K. Franco, R. Cohen, and F. Motlow, “Use of complementary therapy by adolescents with asthma,” Archives of Pediatrics and Adolescent Medicine, vol. 156, no. 10, pp. 1042–1044, 2002. View at Google Scholar · View at Scopus
  5. L. E. M. Hagen, R. Schneider, D. Stephens, D. Modrusan, and B. M. Feldman, “Use of complementary and alternative medicine by pediatric rheumatology patients,” Arthritis Care and Research, vol. 49, no. 1, pp. 3–6, 2003. View at Google Scholar · View at Scopus
  6. A. S. Day, “Use of complementary and alternative therapies and probiotic agents by children attending gastroenterology outpatient clinics,” Journal of Paediatrics and Child Health, vol. 38, no. 4, pp. 343–346, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. A. S. Day, K. E. Whitten, and T. D. Bohane, “Use of complementary and alternative medicines by children and adolescents with inflammatory bowel disease,” Journal of Paediatrics and Child Health, vol. 40, no. 12, pp. 681–684, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. A. M. Vlieger, M. Blink, E. Tromp, and M. A. Benninga, “Use of complementary and alternative medicine by pediatric patients with functional and organic gastrointestinal diseases: results from a multicenter survey,” Pediatrics, vol. 122, no. 2, pp. e446–e451, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. P. Wong, A. L. Clark, E. A. Garnett et al., “Use of complementary medicine in pediatric patients with inflammatory bowel disease: results from a multicenter survey,” Journal of Pediatric Gastroenterology and Nutrition, vol. 48, no. 1, pp. 55–60, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Heuschkel, N. Afzal, A. Wuerth et al., “Complementary medicine use in children and young adults with inflammatory bowel disease,” The American Journal of Gastroenterology, vol. 97, no. 2, pp. 382–388, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. S. E. Levy and S. L. Hyman, “Use of complementary and alternative treatments: for children with autistic spectrum disorders is increasing,” Pediatric Annals, vol. 32, no. 10, pp. 685–691, 2003. View at Google Scholar · View at Scopus
  12. J. W. Harrington, L. Rosen, A. Garnecho, and P. A. Patrick, “Parental perceptions and use of complementary and alternative medicine practices for children with autistic spectrum disorders in private practice,” Journal of Developmental and Behavioral Pediatrics, vol. 27, no. 2, pp. S156–S161, 2006. View at Google Scholar · View at Scopus
  13. E. A. Hurvitz, C. Leonard, R. Ayyangar, and V. S. Nelwson, “Complementary and alternative medicine use in families of children with cerebral palsy,” Developmental Medicine and Child Neurology, vol. 45, no. 6, pp. 364–370, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Soo, J. K. Mah, K. Barlow, L. Hamiwka, and E. Wirrell, “Use of complementary and alternative medical therapies in a pediatric neurology clinic,” Canadian Journal of Neurological Sciences, vol. 32, no. 4, pp. 524–528, 2005. View at Google Scholar · View at Scopus
  15. S. F. Sencer and K. M. Kelly, “Complementary and alternative therapies in pediatric oncology,” Pediatric Clinics of North America, vol. 54, no. 6, pp. 1043–1060, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. K. M. Kelly, J. S. Jacobson, D. D. Kennedy, S. M. Braudt, M. Mallick, and M. A. Weiner, “Use of unconventional therapies by children with cancer at an urban medical center,” Journal of Pediatric Hematology/Oncology, vol. 22, no. 5, pp. 412–416, 2000. View at Google Scholar · View at Scopus
  17. M. A. Grootenhuis, B. F. Last, J. H. de Graaf-Nijkerk, and M. van der Wel, “Use of alternative treatment in pediatric oncology,” Cancer Nursing, vol. 21, no. 4, pp. 282–288, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. C. V. Fernandez, C. A. Stutzer, L. MacWilliam, and C. Fryer, “Alternative and complementary therapy use in pediatric oncology patients in British Columbia: prevalence and reasons for use and nonuse,” Journal of Clinical Oncology, vol. 16, no. 4, pp. 1279–1286, 1998. View at Google Scholar · View at Scopus
  19. M. G. Sawyer, A. F. Gannoni, I. R. Toogood, G. Antoniou, and M. Rice, “The use of alternative therapies by children with cancer,” Medical Journal of Australia, vol. 160, no. 6, pp. 320–322, 1994. View at Google Scholar · View at Scopus
  20. D. Martel, J. F. Bussières, Y. Théorêt et al., “Use of alternative and complementary therapies in children with cancer,” Pediatric Blood and Cancer, vol. 44, no. 7, pp. 660–668, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Roth, J. Lin, M. Kim, and K. Moody, “Pediatric oncologists' views toward the use of complementary and alternative medicine in children with cancer,” Journal of Pediatric Hematology/Oncology, vol. 31, no. 3, pp. 177–182, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Adams, S. Dagenais, T. Clifford et al., “Complementary and alternative medicine use by pediatric specialty outpatients,” Pediatrics, vol. 131, pp. 225–232, 2013. View at Publisher · View at Google Scholar
  23. P. M. Barnes, B. Bloom, and R. L. Nahin, “Complementary and alternative medicine use among adults and children: United States, 2007,” National Health Statistics Reports, vol. 12, pp. 1–23, 2008. View at Google Scholar · View at Scopus
  24. C. Karadeniz, F. G. Pinarli, A. Oǧuz, T. Gürsel, and B. Canter, “Complementary/alternative medicine use in a pediatric oncology unit in Turkey,” Pediatric Blood and Cancer, vol. 48, no. 5, pp. 540–543, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. M. A. Richardson, L. C. Mâsse, K. Nanny, and C. Sanders, “Discrepant views of oncologists and cancer patients on complementary/alternative medicine,” Supportive Care in Cancer, vol. 12, no. 11, pp. 797–804, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. E. A. McCurdy, J. G. Spangler, M. M. Wofford, A. R. Chauvenet, and T. W. McLean, “Religiosity is associated with the use of complementary medical therapies by pediatric oncology patients,” Journal of Pediatric Hematology/Oncology, vol. 25, no. 2, pp. 125–129, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Molassiotis and D. Cubbin, “Thinking outside the box: complementary and alternative therapies use in paediatric oncology patients,” European Journal of Oncology Nursing, vol. 8, no. 1, pp. 50–60, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Friedman, W. B. Slayton, L. S. Allen et al., “Use of alternative therapies for children with cancer,” Pediatrics, vol. 100, no. 6, article E1, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. P. C. Fletcher and J. Clarke, “The use of complementary and alternative medicine among pediatric patients,” Cancer Nursing, vol. 27, no. 2, pp. 93–99, 2004. View at Google Scholar · View at Scopus
  30. K. A. Conklin, “Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects,” Nutrition and Cancer, vol. 37, no. 1, pp. 1–18, 2000. View at Google Scholar · View at Scopus
  31. D. D. Kennedy, E. J. Ladas, S. R. Rheingold, J. Blumberg, and K. M. Kelly, “Antioxidant status decreases in children with acute lymphoblastic leukemia during the first six months of chemotherapy treatment,” Pediatric Blood and Cancer, vol. 44, no. 4, pp. 378–385, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Larussi, U. Auricchio, A. Agretto et al., “Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: control study in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma,” Molecular Aspects of Medicine, vol. 15, pp. s207–s212, 1994. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Pirovano, A. Balzarini, S. Bohm, S. Oriana, G. B. Spatti, and F. Zunino, “Peripheral neurotoxicity following high-dose cisplatin with glutathione: clinical and neurophysiological assessment,” Tumori, vol. 78, no. 4, pp. 253–257, 1992. View at Google Scholar · View at Scopus
  34. F. Di Re, S. Bohm, S. Oriana, G. B. Spatti, and F. Zunino, “Efficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protection in the treatment of bulky advanced epithelial ovarian cancer,” Cancer Chemotherapy and Pharmacology, vol. 25, no. 5, pp. 355–360, 1990. View at Google Scholar · View at Scopus
  35. J. F. Smyth, A. Bowman, T. Perren et al., “Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarlan cancer treated with cisplatin: results of a double-blind, randomised trail,” Annals of Oncology, vol. 8, no. 6, pp. 569–573, 1997. View at Google Scholar · View at Scopus
  36. H. Pohl and J. A. Reidy, “Vitamin C intake influences the bleomycin-induced chromosome damage assay: implications for detection of cancer susceptibility and chromosome breakage syndromes,” Mutation Research, vol. 224, no. 2, pp. 247–252, 1989. View at Google Scholar · View at Scopus
  37. I. Bairati, F. Meyer, M. Gélinas et al., “Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients,” Journal of Clinical Oncology, vol. 23, no. 24, pp. 5805–5813, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. L. B. Michaud, J. P. Karpinski, K. L. Jones, and J. Espirito, “Dietary supplements in patients with cancer: risks and key concepts, part 1,” The American Journal of Health-System Pharmacy, vol. 64, no. 4, pp. 369–381, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Seely, D. Stempak, and S. Baruchel, “A strategy for controlling potential interactions between natural health products and chemotherapy: a review in pediatric oncology,” Journal of Pediatric Hematology/Oncology, vol. 29, no. 1, pp. 32–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Chinery, J. A. Brockman, M. O. Peeler, Y. Shyr, R. D. Beauchamp, and R. J. Coffey, “Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta,” Nature Medicine, vol. 3, no. 11, pp. 1233–1241, 1997. View at Google Scholar · View at Scopus
  41. E. J. Ladas, J. S. Jacobson, D. D. Kennedy, K. Teel, A. Fleischauer, and K. M. Kelly, “Antioxidants and cancer therapy: a systematic review,” Journal of Clinical Oncology, vol. 22, no. 3, pp. 517–528, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. L. B. Michaud, J. P. Karpinski, K. L. Jones, and J. Espirito, “Dietary supplements in patients with cancer: risks and key concepts, part 2,” The American Journal of Health-System Pharmacy, vol. 64, no. 5, pp. 467–480, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Lersch, M. Zeuner, A. Bauer et al., “Nonspecific immunostimulation with low doses of cyclophosphamide (LDCY), thymostimulin, and echinacea purpurea extracts (echinacin) in patients with far advanced colorectal cancers: preliminary results,” Cancer Investigation, vol. 10, no. 5, pp. 343–348, 1992. View at Google Scholar · View at Scopus
  44. D. Melchart, C. Clemm, B. Weber et al., “Polysaccharides isolated from Echinacea purpurea herba cell cultures to counteract undesired effects of chemotherapy—A pilot study,” Phytotherapy Research, vol. 16, no. 2, pp. 138–142, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. K. I. Block and M. N. Mead, “Immune system effects of echinacea, ginseng, and astragalus: a review,” Integrative Cancer Therapies, vol. 2, no. 3, pp. 247–267, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Bold and A. Leis, “Unconventional therapy use among children with cancer in Saskatchewan,” Journal of Pediatric Oncology Nursing, vol. 18, no. 1, pp. 16–25, 2001. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Sparreboom, M. C. Cox, M. R. Acharya, and W. D. Figg, “Herbal remedies in the United States: potential adverse interactions with anticancer agents,” Journal of Clinical Oncology, vol. 22, no. 12, pp. 2489–2503, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. B. C. Foster, “Therapeutic product disposition in at-risk populations,” Radiation Protection Dosimetry, vol. 134, no. 3-4, pp. 184–190, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. K. T. Kivisto, H. K. Kroemer, and M. Eichelbaum, “The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions,” The British Journal of Clinical Pharmacology, vol. 40, no. 6, pp. 523–530, 1995. View at Google Scholar · View at Scopus
  50. G. I. Murray, P. J. Paterson, R. J. Weaver et al., “The expression of cytochrome P-450, epoxide hydrolase, and glutathione S-transferase in hepatocellular carcinoma,” Cancer, vol. 71, no. 1, pp. 36–43, 1993. View at Google Scholar
  51. G. I. Murray, R. J. Weaver, P. J. Paterson, S. W. B. Ewen, W. T. Melvin, and M. D. Burke, “Expression of xenobiotic metabolizing enzymes in breast cancer,” Journal of Pathology, vol. 169, no. 3, pp. 347–353, 1993. View at Google Scholar · View at Scopus
  52. T. W. Tam, H. Akhtar, J. T. Arnason et al., “Inhibition of human cytochrome P450 metabolism by blended herbal products and vitamins,” Journal of Pharmacy and Pharmaceutical Sciences, vol. 14, no. 1, pp. 1–16, 2011. View at Google Scholar · View at Scopus
  53. Sense About Science, “I’ve got nothing to lose by trying it: weighing up claims about cures and treatments for medical conditions,” 2013, www.senseaboutscience.org/resources.php/136/ive-got-nothing-to-lose-by-trying-it.
  54. S. Punja, M. Langevin, S. Sencer et al., “Establishing a comprehensive pediatric integrative oncology program,” in Integrative Pediatric Oncology, A. Längler, P. J. Mansky, and G. Seifert, Eds., pp. 187–200, Springer, London, UK, 2012. View at Google Scholar
  55. D. Wang, D. Adams, H. Amrenic et al., “Pediatric integrative medicine as it is practiced in Canada, a survey of Ontario chiropractors, naturopaths, and osteopaths,” Journal of Complementary and Integrative Medicine, vol. 5, no. 1, article 31, p. 58, 2008. View at Google Scholar
  56. J. Gilmour, C. Harrison, M. H. Cohen, and S. Vohra, “Pediatric use of complementary and alternative medicine: legal, ethical, and clinical issues in decision-making,” Pediatrics, vol. 128, no. 4, pp. S149–S154, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. S. P. Murphy, L. R. Wilkens, J. H. Hankin et al., “Comparison of two instruments for quantifying intake of vitamin and mineral supplements: a brief questionnaire versus three 24-hour recalls,” The American Journal of Epidemiology, vol. 156, no. 7, pp. 669–675, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. J. Armishaw and C. C. Grant, “Use of complementary treatment by those hospitalised with acute illness,” Archives of Disease in Childhood, vol. 81, no. 2, pp. 133–137, 1999. View at Google Scholar · View at Scopus
  59. L. J. Mazur, L. De Ybarrondo, J. Miller, and G. Colasurdo, “Use of alternative and complementary therapies for pediatric asthma,” Texas Medicine, vol. 97, no. 6, pp. 64–68, 2001. View at Google Scholar · View at Scopus
  60. S. E. Levy, D. S. Mandell, S. Merhar, R. F. Ittenbach, and J. A. Pinto-Martin, “Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder,” Journal of Developmental and Behavioral Pediatrics, vol. 24, no. 6, pp. 418–423, 2003. View at Publisher · View at Google Scholar · View at Scopus
  61. G. A. Johnston, R. M. Bilbao, and R. A. C. Graham-Brown, “The use of dietary manipulation by parents of children with atopic dermatitis,” The British Journal of Dermatology, vol. 150, no. 6, pp. 1186–1189, 2004. View at Publisher · View at Google Scholar · View at Scopus
  62. J. Y. Lim, M. Z. Wong, M. Y. Chan et al., “Use of complementary and alternative medicine in paediatric oncology patients in Singapore,” Annals of the Academy of Medicine, vol. 33, no. 5, pp. S76–S77, 2004. View at Google Scholar · View at Scopus
  63. D. Adams, C. Spelliscy, L. Sivakumar et al., “CAM and pediatric oncology: where are all the best cases,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 632351, 6 pages, 2013. View at Publisher · View at Google Scholar
  64. S. Vohra, J. Brulotte, C. Le, T. Charrois, and H. Laeeque, “Adverse events associated with paediatric use of complementary and alternative medicine: Results of a Canadian paediatric surveillance program survey,” Paediatrics and Child Health, vol. 14, no. 6, pp. 385–387, 2009. View at Google Scholar · View at Scopus