Figure 5: The HRE-mediated transcriptional activity induced by the winning population of flavonoid combinations in each iteration In each iteration, the -axis represents the th combination in current winning population. Winning combinations are determined after competition between original combinations and trial combinations, as in Figure 1(S). Values are expressed as the mean value in Figure 4. Initial combinations are comprised of control, AR extract, and individual flavonoid. The FSC scheme iteratively drove combinations in the population towards higher HRE-mediated transcriptional activity; that is, the best response of 3rd combination in the population was found in iteration 3, and carried over through iterations 4 and 5.