Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
Figure 2
Curcumin inhibits tumor growth and liver metastasis in vivo. (a) Illustration of the experimental design showed the metastatic animal model. (b) Red arrow indicates the invaded tumor nodules from spleen to liver. (c) H&E staining of paraffin-embedded tumor sections of vehicle control and curcumin treated mice. Images were acquired under an inverted microscope at 100x and 400x. T: tumor; N: normal tissue (scale bars: 10 m). (d) The body weight of mice was not affected by CUR treatment. (e) Curcumin inhibits primary tumor growth in spleen (normalized with body weight) and (f) liver metastasis. *.
