Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer

Table 1

Transcriptional regulated networks analysis of curcumin affected genes by MetaCore.

No.	Network	GO processes	Total nodes	Seed nodes	𝑃 value
1	Sp-1	Positive regulation of biological process (45.9%; 7.506𝑒−25), developmental process (54.1%; 2.573𝑒−24), positive regulation of cellular process (42.8%; 9.240𝑒−24), anatomical structure development (47.7%; 9.685𝑒−22), and multicellular organismal development (49.5%; 1.323𝑒−21)	223	222	0.000𝐸+00
2	HNF4-alpha	Cellular process (91.7%; 1.582𝑒−14), cellular metabolic process (66.1%; 4.500𝑒−14), cellular macromolecule metabolic process (51.1%; 7.619𝑒−12), regulation of metabolic process (49.4%; 8.376𝑒−12), and regulation of molecular function (28.3%; 3.538𝑒−11)	184	183	0.000𝐸+00
3	c-Myc	Cellular metabolic process (78.5%; 3.246𝑒−28), primary metabolic process (78.5%; 4.624𝑒−28), metabolic process (82.9%; 4.212𝑒−25), nitrogen compound metabolic process (56.9%; 8.284𝑒−23), and cellular process (96.7%; 1.088𝑒−22)	183	182	0.000𝐸+00
4	CREB1	Positive regulation of biological process (51.6%; 4.179𝑒−19), regulation of cellular process (82.8%; 4.212𝑒−18), regulation of biological process (83.6%; 1.163𝑒−16), biological regulation (85.2%; 2.132𝑒−16), and positive regulation of cellular process (45.1%; 1.518𝑒−15)	122	121	1.260𝐸−213
5	p53	Regulation of cell cycle (24.4%; 6.529𝑒−16), negative regulation of biological process (44.5%; 2.372𝑒−15), negative regulation of cellular process (42.0%; 7.092𝑒−15), anatomical structure morphogenesis (34.5%; 9.440𝑒−14), and positive regulation of biological process (45.4%; 1.493𝑒−13)	120	119	5.020𝐸−210
6	ESR1 (nuclear)	Positive regulation of biological process (51.7%; 1.418𝑒−18), positive regulation of cellular process (49.2%; 1.607𝑒−18), regulation of metabolic process (61.9%; 1.599𝑒−16), regulation of macromolecule metabolic process (54.2%; 1.174𝑒−15), and negative regulation of biological process (44.9%; 1.529𝑒−15)	118	117	1.990𝐸−206
7	AP-1	Negative regulation of biological process (55.3%; 3.643𝑒−22), negative regulation of cellular process (51.5%; 1.486𝑒−20), response to stress (53.4%; 3.747𝑒−20), positive regulation of cellular process (52.4%; 5.642𝑒−19), and positive regulation of biological process (52.4%; 5.840𝑒−17)	104	104	4.170𝐸−185
8	EGR1	Regulation of molecular function (45.5%; 4.341𝑒−19), positive regulation of biological process (54.5%; 3.071𝑒−18), developmental process (61.4%; 7.639𝑒−17), anatomical structure development (56.4%; 1.693𝑒−16), and positive regulation of cellular process (49.5%; 2.508𝑒−16)	101	100	6.280𝐸−176
9	NF-𝜅B	Positive regulation of cellular process (53.2%; 5.019𝑒−18), negative regulation of biological process (52.1%; 8.477𝑒−18), positive regulation of biological process (55.3%; 1.013𝑒−17), response to stress (52.1%; 1.554𝑒−17), and regulation of programmed cell death (36.2%; 3.551𝑒−17)	96	95	5.510𝐸−167
10	E2F1	Regulation of cell cycle (36.3%; 5.835𝑒−24), regulation of macromolecule metabolic process (69.2%; 2.822𝑒−23), regulation of primary metabolic process (70.3%; 1.619𝑒−22), regulation of cellular metabolic process (70.3%; 2.142𝑒−22), and regulation of metabolic process (73.6%; 1.740𝑒−21)	93	92	1.260𝐸−161