Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
Effect of KIOM-79 treatment on AGEs accumulation in the heart. (a) Representative immunohistochemistry images for AGEs (a) staining in the heart of ZL rats (A), untreated ZDF rats (B), ZDF rats treated with KIOM-79 (50 mg/kg) (C), and ZDF rats treated with KIOM-79 (500 mg/kg) (D). Original magnification: ×400. (b) Quantitative analysis of AGEs stain was calculated. ((c) and (d)) Western blot analysis of AGEs in cardiac tissue. The nonenzymatic reaction of the amino groups of cellular proteins with reducing sugars forms a variety of AGEs. Thus, the multiple bands for advanced glycation adducts were detected. All data were expressed as the mean ± S.E.M. * compared to ZL rats; # compared to untreated ZDF rats.
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