Evidence-Based Complementary and Alternative Medicine

Research Article

In Vitro Evaluations of Cytotoxicity of Eight Antidiabetic Medicinal Plants and Their Effect on GLUT4 Translocation

Table 1

GLUT4 translocation and EC₅₀ of plant extracts in cells from HepG2 and L6myc cell lines. Data given represent the mean ± SEM from three independent experiments carried out in triplicates.


Plant name	Part used	Cell type	EC₅₀ (mg/mL)	Cell surface* GLUT4myc

Allium sativum	Bulb	L6myc	>2	−
		HepG2	>2
Allium cepa	Bulb	L6myc	>2	−
		HepG2	>2
Trigonella foenum	Seeds	L6myc	>2	++
		HepG2	>2
Olea europaea	Leaves	L6myc	0.79 ± 0.036	− −
		HepG2	>2
Nigella sativa	Seeds	L6myc	>2	+
		HepG2	1.47 ± 0.49
Urtica dioica	Leaves and stem	L6myc	0.73 ± 0.09	++
		HepG2	0.76 ± 0.13
Atriplex halimus	Leaves and stem	L6myc	1.72 ± 0.22	++
		HepG2	0.8 ± 0.3
Cinnamomon cassia	Bark	L6myc	0.39 ± 0. 01	+
		HepG2	0.12 ± 0. 01

*Gain in GLUT4 on plasma membranes at noncytotoxic concentrations, (−) no effect, (− −) decreased GLUT4 translocation, (+) slightly increased the GLUT4 translocation, (++) high GLUT4 translocation.