Attenuation of CCl₄-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

Table 1

Effect of honey on CCl₄-induced hepatotoxicity-related parameters in rats.

Treatment group (𝑛=6)	SGOT (U/L)	SGPT (U/L)	GGT (U/L)	ALP (U/L)	Bilirubin (mg/dL)
Normal control	75.53±2.86	26.93±1.75	3.66±0.37	282.00±10.05	0.52±0.02
CCl4 only (1.25 mL/kg)	300.00±8.23^***a	209.50±8.44^*a	15.45±1.20^***a	671.33±15.15^***a	3.45±0.16^***a
Honey (0.5 g/kg) + CCl4	273.66±10.28^b	182.83±7.61^*b	12.81±0.61^b	614.83±13.41^*b	2.67±0.14^**b
Honey (1.0 g/kg) + CCl4	200.00±5.08^***b	140.83±6.12^***b	10.38±0.54^**b	605.16±12.82^**b	2.01±0.10^***b
Silymarin (10 mg/kg) + CCl4	133.58±8.08^***b	106.78±6.33^***b	5.08±0.30^***b	416.16±11.62^***b	1.17±0.10^***b

All values represent mean ± SEM. *𝑃<0.05; **𝑃<0.01; ***𝑃<0.001; ANOVA, followed by Dunnett’s multiple comparison test.
^aAs compared with normal group. ^bAs compared with CCl₄ only group.