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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 579346, 10 pages
http://dx.doi.org/10.1155/2013/579346
Research Article

Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of Croton campestris A. St.-Hill in Rodents

Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil

Received 20 February 2013; Revised 24 May 2013; Accepted 27 May 2013

Academic Editor: Ulysses Paulino de Albuquerque

Copyright © 2013 Francisco E. B. Júnior et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.