Matrine Inhibits Infiltration of the Inflammatory Gr1^hi Monocyte Subset in Injured Mouse Liver through Inhibition of Monocyte Chemoattractant Protein-1

Figure 3

Mat inhibited the recruitment of Gr1^hi monocytes into acute liver injury. C57BL/6 mice were injected i.p. with CCl₄ (0.6 mL/kg). Mat (30 mg/kg) was administrated orally 3 h before CCl₄ injection. NPCs were isolated from livers of different experimental groups at 24 after CCl₄ injection. (a) The total number of NPCs, (b) the percentage of CD45⁺ leukocytes in NPCs, (c) the absolute number of CD45⁺ leukocytes in NPCs, (d) the percentage of different monocyte subsets in NPCs, and (e) the absolute number of different monocyte subsets were analyzed by flow cytometry. Data are expressed as the mean ± (SD) (𝑛=8 mice/group). ^∗𝑃<0.05 versus CCl₄-only group; ^#𝑃<0.05 versus normal control group.

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