Matrine Inhibits Infiltration of the Inflammatory Monocyte Subset in Injured Mouse Liver through Inhibition of Monocyte Chemoattractant Protein-1
Figure 4
Administration of Mat reduced MCP-1 production in CCl4-challenge mice. C57BL/6 mice were injected i.p. with CCl4 (0.6 mL/kg). Mat (30 mg/kg) was administrated orally 3 h before CCl4 injection. (a) Sera were collected and analyzed for MCP-1 levels 24 h after CCl4 injection. (b) Liver tissues were collected 24 h after CCl4 injection and analyzed for MCP-1 mRNA levels with real-time PCR. Data in (a) and (b) are expressed as the mean ± (SD) ( mice/group). versus CCl4-only group; versus normal control group. (c) Liver tissues were collected 24 h after CCl4 injection; paraffin sections were made and analyzed for MCP-1 with immunohistochemistry (original magnification ×200).
