The Predicted Proteomic Network Associated with the Antiarthritic Action of Qingfu Guanjieshu in Collagen-II-Induced Arthritis in Rats
The predicted proteomic network identified by String Software resembling potential connections and interactions among the differentially expressed proteins associated with the anti-arthritic effect of QFGJS in CIA rats. The jointed lines represent the predicted protein-protein connections and correlations among the network including neighborhood, gene fusion, cooccurrence, and coexpression. The color points (arrow pointed) represent the proteins identified in the synovial tissues with functions involved in metabolic processes. The white points represent the proteins which have been reported in the literature, databases, text mining or showing homology. Although differential expression of apolipoprotein C-III, Pgam1, and Gpx1 had been demonstrated among the normal and vehicle-treated CIA and QFGJS-treated CIA rats after 2D gel analysis, these proteins with rat’s origin were not found in the database of String Software; therefore, they were not included in the diagram.