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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 586741, 10 pages
http://dx.doi.org/10.1155/2013/586741
Research Article

Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone Morphogenetic Protein-2/Smad-Dependent Runx2 Pathway

Department of Prescriptionology, College of Korean Medicine, Kyung Hee University, 26 Kyunghee Dae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Received 2 April 2013; Accepted 1 July 2013

Academic Editor: Chang Shik Yin

Copyright © 2013 Do Rim Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. van Damme, T. Vanden Driessche, D. Collen, and M. K. L. Chuah, “Bone marrow stromal cells as targets for gene therapy,” Current Gene Therapy, vol. 2, no. 2, pp. 195–209, 2002. View at Google Scholar · View at Scopus
  2. C. M. Kolf, E. Cho, and R. S. Tuan, “Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation,” Arthritis Research and Therapy, vol. 9, no. 1, article 204, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Tschöpe, K. Miteva, H.-P. Schultheiss, and S. van Linthout, “Mesenchymal stromal cells: a promising cell source for the treatment of inflammatory cardiomyopathy,” Current Pharmaceutical Design, vol. 17, no. 30, pp. 3295–3307, 2011. View at Google Scholar · View at Scopus
  4. G. Chamberlain, J. Fox, B. Ashton, and J. Middleton, “Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing,” Stem Cells, vol. 25, no. 11, pp. 2739–2749, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. H.-J. Ahn, W.-J. Lee, K. Kwack, and Y. D. Kwon, “FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling,” FEBS Letters, vol. 583, no. 17, pp. 2922–2926, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Levy, T. Dvir, O. Tsur-Gang, Y. Granot, and S. Cohen, “Signal transducer and activator of transcription 3-A key molecular switch for human mesenchymal stem cell proliferation,” International Journal of Biochemistry and Cell Biology, vol. 40, no. 11, pp. 2606–2618, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Summer and A. Fine, “Mesenchymal progenitor cell research limitations and recommendations,” Proceedings of the American Thoracic Society, vol. 5, no. 6, pp. 707–710, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. P. J. Park, B. S. Moon, S. H. Lee et al., “Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling,” Life Sciences, vol. 91, pp. 935–943, 2012. View at Google Scholar
  9. S. Nadri, M. Soleimani, R. H. Hosseni, M. Massumi, A. Atashi, and R. Izadpanah, “An efficient method for isolation of murine bone marrow mesenchymal stem cells,” International Journal of Developmental Biology, vol. 51, no. 8, pp. 723–729, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M. B. Eslaminejad and S. Nadri, “Murine mesenchymal stem cell isolated and expanded in low and high density culture system: surface antigen expression and osteogenic culture mineralization,” In Vitro Cellular and Developmental Biology—Animal, vol. 45, no. 8, pp. 451–459, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. R. K. Saiki, T. L. Bugawan, G. T. Horn, K. B. Mullis, and H. A. Erlich, “Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes,” Nature, vol. 324, no. 6093, pp. 163–166, 1986. View at Google Scholar · View at Scopus
  12. P. Tong, C. Wu, X. Wang et al., “Development and assessment of a complete-detoxi arthritis cation strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid therapy,” Journal of Ethnopharmacology, vol. 146, no. 2, pp. 562–571, 2013. View at Publisher · View at Google Scholar
  13. J. Singhuber, M. Zhu, S. Prinz, and B. Kopp, “Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk?” Journal of Ethnopharmacology, vol. 126, no. 1, pp. 18–30, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Nadri and M. Soleimani, “Isolation murine mesenchymal stem cells by positive selection,” In Vitro Cellular and Developmental Biology—Animal, vol. 43, no. 8-9, pp. 276–282, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Ohishi and E. Schipani, “Bone marrow mesenchymal stem cells,” Journal of Cellular Biochemistry, vol. 109, no. 2, pp. 277–282, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Tögel and C. Westenfelder, “Adult bone marrow-derived stem cells for organ regeneration and repair,” Developmental Dynamics, vol. 236, no. 12, pp. 3321–3331, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Baddoo, K. Hill, R. Wilkinson et al., “Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection,” Journal of Cellular Biochemistry, vol. 89, no. 6, pp. 1235–1249, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Ozawa, K. Sato, I. Oh et al., “Cell and gene therapy using mesenchymal stem cells (MSCs),” Journal of Autoimmunity, vol. 30, no. 3, pp. 121–127, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. R. S. Tuan, G. Boland, and R. Tuli, “Adult mesenchymal stem cells and cell-based tissue engineering,” Arthritis Research and Therapy, vol. 5, no. 1, pp. 32–45, 2003. View at Google Scholar · View at Scopus
  20. J.-F. Zhang, G. Li, C.-Y. Chan et al., “Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway,” Molecular and Cellular Endocrinology, vol. 314, no. 1, pp. 70–74, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. R. Junttila, S.-P. Li, and J. Westermarck, “Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival,” FASEB Journal, vol. 22, no. 4, pp. 954–965, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. A. McCubrey, L. S. Steelman, S. L. Abrams et al., “Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance,” Advances in Enzyme Regulation, vol. 46, no. 1, pp. 249–279, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Lin, S.-D. Dai, and G.-Y. Fan, “Glucocorticoid-induced differentiation of primary cultured bone marrow mesenchymal cells into adipocytes is antagonized by exogenous Runx2,” APMIS, vol. 118, no. 8, pp. 595–605, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Nishimura, K. Hata, F. Ikeda et al., “Signal transduction and transcriptional regulation during mesenchymal cell differentiation,” Journal of Bone and Mineral Metabolism, vol. 26, no. 3, pp. 203–212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. E. Phillips, C. A. Gersbach, A. M. Wojtowicz, and A. J. García, “Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation,” Journal of Cell Science, vol. 119, no. 3, pp. 581–591, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. Z. Hamidouche, E. Haÿ, P. Vaudin et al., “FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/β-catenin signaling-dependent Runx2 expression,” FASEB Journal, vol. 22, no. 11, pp. 3813–3822, 2008. View at Publisher · View at Google Scholar · View at Scopus