Decrease of Obesity by Allantoin via Imidazoline I1-Receptor Activation in High Fat Diet-Fed Mice
Figure 4
Changes in the hypothalamic NPY level in HFD-fed mice treated with allantoin for 8 weeks. HFD-fed mice received continuous administration of allantoin (5 mg/kg, i.p. three times per day), while another group was pretreated with efaroxan (1.5 mg/kg) 30 min before the administration of allantoin. The values are expressed as the mean ± SEM from each group of eight animals compared with the normal chow-fed group; compared with the vehicle-treated HFD-fed group.
