Decrease of Obesity by Allantoin via Imidazoline I₁-Receptor Activation in High Fat Diet-Fed Mice

Table 2

The inhibitory effect of allantoin on hyperleptinemia in HFD-fed mice treated with allantoin for 8 weeks. HFD-fed mice received continuous administration of allantoin (5 mg/kg, i.p. three times per day), while another group was pretreated with efaroxan (1.5 mg/kg, i.p.) 30 min prior to the administration of allantoin.

	Leptin (ng/mL)
Normal mice	18.84 ± 1.36^###
HFD-fed mice
+vehicle	59.83 ± 1.05***
+allantoin	17.21 ± 0.82^###
+efaroxan and allantoin	61.86 ± 2.25***

Values were obtained from each group of eight animals and expressed as the mean ± SEM. ***P < 0.001 compared with the normal chow-fed mice group; ^###P < 0.001 compared with the vehicle-treated HFD-fed mice group.