Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract: The Traditional Herbal Formula in Rats

Table 6

Serum biochemical values of rats treated orally with SST for 13 weeks.

Parameters	Male				Female
	Control	500 mg/kg	1000 mg/kg	2000 mg/kg	Control	500 mg/kg	1000 mg/kg	2000 mg/kg
GLU (mg/dL)	137.4 ± 44.22	121.6 ± 24.25	111.5 ± 20.60	125.2 ± 35.90	155.3 ± 27.24	138.2 ± 18.97	128.8 ± 29.05	144.5 ± 21.23
BUN (mg/dL)	14.6 ± 1.45	14.4 ± 1.31	13.8 ± 1.92	14.7 ± 1.02	18.7 ± 2.38	16.0 ± 1.95	17.5 ± 2.19	17.1 ± 2.32
CREA (mg/dL)	0.56 ± 0.052	0.55 ± 0.061	0.57 ± 0.063	0.56 ± 0.052	0.71 ± 0.046	0.69 ± 0.050	0.69 ± 0.054	0.69 ± 0.086
TP (g/dL)	6.98 ± 0.387	6.96 ± 0.228	6.85 ± 0.290	7.08 ± 0.283	7.86 ± 0.374	7.93 ± 0.459	7.78 ± 0.470	8.13 ± 0.584
ALB (g/dL)	4.49 ± 0.156	4.49 ± 0.108	4.40 ± 0.116	4.54 ± 0.166	5.21 ± 0.265	5.28 ± 0.258	5.23 ± 0.262	5.38 ± 0.310
A/G (ratio)	1.82 ± 0.149	1.83 ± 0.125	1.81 ± 0.151	1.80 ± 0.148	1.97 ± 0.093	2.00 ± 0.112	2.06 ± 0.086	1.97 ± 0.136
TCHO (mg/dL)	70.3 ± 22.49	71.8 ± 12.37	64.9 ± 14.67	73.8 ± 16.34	91.4 ± 24.91	89.6 ± 17.10	95.2 ± 18.61	91.3 ± 24.44
TG (mg/dL)	55.4 ± 22.90	55.1 ± 16.17	50.6 ± 14.86	67.2 ± 35.73	60.7 ± 27.67	42.1 ± 8.77	47.3 ± 10.10	51.2 ± 14.93
PL (mg/dL)	102 ± 22.7	107 ± 16.5	96 ± 15.7	110 ± 22.8	169 ± 38.3	162 ± 20.9	170 ± 25.9	169 ± 36.2
AST (IU/L)	124.9 ± 29.29	117.1 ± 13.76	122.3 ± 18.48	114.1 ± 14.50	116.6 ± 34.14	142.1 ± 73.28	138.1 ± 29.01	115.1 ± 22.97
ALT (IU/L)	35.9 ± 8.43	33.6 ± 5.45	33.1 ± 8.90	33.6 ± 5.25	32.5 ± 10.83	49.3 ± 46.80	49.5 ± 14.82	35.6 ± 14.54
TBIL (mg/dL)	0.157 ± 0.01	0.141 ± 0.01	0.133 ± 0.02*	0.149 ± 0.01	0.178 ± 0.01	0.183 ± 0.02	0.154 ± 0.02	0.192 ± 0.03
ALP (IU/L)	214.1 ± 29.52	241.9 ± 28.77	241.2 ± 40.68	230.2 ± 25.28	124.2 ± 34.46	117.5 ± 25.35	137.5 ± 46.11	125.0 ± 21.91
CK (IU/L)	623 ± 197.7	579 ± 154.9	622 ± 162.4	581 ± 212.6	550 ± 244.5	549 ± 138.0	534 ± 209.3	468 ± 162.6
Ca (mg/dL)	11.08 ± 0.36	11.22 ± 0.37	11.03 ± 0.38	11.49 ± 0.45	11.88 ± 0.51	11.83 ± 0.36	11.71 ± 0.46	12.30 ± 0.49
IP (mg/dL)	9.12 ± 1.48	9.13 ± 0.60	8.55 ± 0.65	9.29 ± 0.65	7.01 ± 1.069	7.13 ± 1.190	7.01 ± 1.185	7.95 ± 1.101
Na (mmol/L)	145 ± 2.7	146 ± 2.7	147 ± 2.3	148 ± 0.9	147 ± 2.3	146 ± 1.1	146 ± 1.8	147 ± 1.5
K (mmol/L)	8.26 ± 2.20	8.32 ± 1.49	7.43 ± 1.27	7.83 ± 0.69	6.81 ± 0.765	7.04 ± 1.075	7.22 ± 1.294	7.78 ± 1.469
CI (mmol/L)	101 ± 0.7	102 ± 1.5	102 ± 1.5	102 ± 1.6	104 ± 1.4	103 ± 1.3	104 ± 1.0	102 ± 1.4

∗Significant differences from control group (𝑃<0.05).