Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract: The Traditional Herbal Formula in Rats

Table 7

Relative organ weights of rats treated orally with SST (percentage of body weight) for 13 weeks.

Parameters	Male				Female
	Control	500 mg/kg	1000 mg/kg	2000 mg/kg	Control	500 mg/kg	1000 mg/kg	2000 mg/kg
Brain	0.379 ± 0.03	0.372 ± 0.02	0.388 ± 0.02	0.378 ± 0.02	0.665 ± 0.049	0.644 ± 0.054	0.681 ± 0.056	0.681 ± 0.083
Pituitary gland	0.002 ± 0.0002	0.002 ± 0.0002	0.002 ± 0.0002	0.002 ± 0.0003	0.006 ± 0.0006	0.006 ± 0.0007	0.006 ± 0.0010	0.006 ± 0.0008
Liver	2.771 ± 0.216	2.718 ± 0.239	2.700 ± 0.224	2.848 ± 0.228	2.755 ± 0.165	2.784 ± 0.100	2.778 ± 0.112	2.938 ± 0.120^#
Spleen	0.160 ± 0.023	0.157 ± 0.022	0.157 ± 0.018	0.163 ± 0.019	0.184 ± 0.025	0.185 ± 0.014	0.180 ± 0.024	0.198 ± 0.028
Heart	0.285 ± 0.026	0.276 ± 0.014	0.273 ± 0.019	0.269 ± 0.017	0.323 ± 0.021	0.315 ± 0.020	0.338 ± 0.019	0.347 ± 0.022*
Thymus	0.084 ± 0.022	0.072 ± 0.008	0.074 ± 0.009	0.140 ± 0.022	0.114 ± 0.035	0.109 ± 0.025	0.119 ± 0.012	0.120 ± 0.019
Salivary glands	0.137 ± 0.019	0.141 ± 0.018	0.140 ± 0.022	0.141 ± 0.013	0.167 ± 0.019	0.162 ± 0.013	0.172 ± 0.012	0.171 ± 0.022
Seminal vesicle	0.373 ± 0.054	0.388 ± 0.057	0.408 ± 0.049	0.347 ± 0.065
Prostate	0.124 ± 0.039	0.128 ± 0.027	0.114 ± 0.027	0.118 ± 0.029
Kidneys	0.695 ± 0.066	0.689 ± 0.073	0.696 ± 0.056	0.673 ± 0.043	0.699 ± 0.059	0.736 ± 0.037	0.758 ± 0.046*	0.774 ± 0.056^#
Adrenal glands	0.013 ± 0.001	0.012 ± 0.001	0.011 ± 0.001	0.012 ± 0.001	0.028 ± 0.003	0.026 ± 0.002	0.027 ± 0.003	0.028 ± 0.004
Testis (female: ovary)	0.652 ± 0.07	0.619 ± 0.08	0.660 ± 0.05	0.644 ± 0.048	0.033 ± 0.006	0.034 ± 0.003	0.037 ± 0.005	0.038 ± 0.007
Epididymides (female: uterus/cervix)	0.281 ± 0.0318	0.276 ± 0.022	0.284 ± 0.018	0.290 ± 0.029	0.248 ± 0.061	0.208 ± 0.051	0.228 ± 0.052	0.238 ± 0.047
Lung	0.305 ± 0.027	0.302 ± 0.023	0.316 ± 0.014	0.296 ± 0.027	0.446 ± 0.04	0.427 ± 0.03	0.458 ± 0.03	0.507 ± 0.09
Thyroid/parathyroid	0.005 ± 0.001	0.005 ± 0.0009	0.005 ± 0.0013	0.005 ± 0.0011	0.007 ± 0.001	0.007 ± 0.001	0.006 ± 0.001	0.007 ± 0.001

∗Significant differences from control group (𝑃<0.05) ^#Significant differences from control group (𝑃<0.05).