The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1
Figure 2
Effect of ALA on HO-1 expression and Nrf2 translocation in lungs instilled by LPS. Rats were treated with ALA (100 mg/kg, i.p.) 1 h before or 3 h after intratracheal instillation of LPS (5 mg/kg) for 6 h. Lungs were harvested for HO-1 protein expression by Western blot (a), and Nrf2 translocation assays with immunofluorescence staining (b). Rats received with vehicle (i.p.) and intratracheal instillation of PBS alone acted as control group. Data were represented as means ± SEM (). *; ** versus LPS-instilled alone group.
