The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

Figure 3

Effect of SnPP on the inhibition of ALA on LPS-induced neutrophil accumulation in BALF and lung MPO activity. Rats were intraperitoneally injected with ALA 1 h before or 3 h after intratracheal instillation of LPS (5 mg/kg). To investigate the role of HO-1, SnPP (50 mg/kg, i.p.) was administered 2 h and ALA 1 h before LPS instillation. The total leukocyte counts in BALF (a) and lung MPO activity (b) were measured at 6 h after LPS instillation. Data were presented as means ± SEM (𝑛=5). *𝑃<0.05; **𝑃<0.01 versus LPS-instilled alone group; ^#𝑃<0.05 versus LPS+ALA group.

(a)

(b)