The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

Figure 5

Effect of SnPP on the improvement of ALA on LPS-induced lung histopathological changes. Rats were intraperitoneally injected with ALA 1 h before or 3 h after intratracheal instillation of LPS. In some rats, SnPP was administered 2 h and ALA 1 h before LPS instillation. The histopathological assays (200× magnification) in lungs were performed at 6 h after LPS instillation in control group (a), LPS-instilled alone group (b), ALA (posttreatment)+LPS group (c), ALA (pretreatment)+LPS group (d), SnPP+ALA (pretreatment)+LPS group (e). The lung injury score was also determined (f). Data were represented as means ± SEM (𝑛=5). *𝑃<0.05 versus LPS-instilled alone group; ^#𝑃<0.05 versus LPS+ALA group.

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