The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

Figure 7

Effect of SnPP on the suppression of ALA on LPS-induced O₂⁻ formation in lungs. Rats were pretreated with ALA 1 h before intratracheal instillation of LPS for 6 h. In some rats, SnPP was administered 2 h and ALA 1 h before LPS instillation. The lung O₂⁻ formation was measured by lucigenin chemiluminescence (a) and DHE immunofluorescent staining (red) (b). Data were represented as means ± SEM (𝑛=5). *𝑃<0.05 versus LPS-instilled alone group; ^#𝑃<0.05 versus LPS+ALA group.

(a)

(b)