Eupafolin and Ethyl Acetate Fraction of Kalanchoe gracilis Stem Extract Show Potent Antiviral Activities against Enterovirus 71 and Coxsackievirus A16

Table 1

Cytotoxicity and antienteroviral activity of KGS extract, fractions, and marker components.

		EV71		COXA16
	CC50 (μg/mL) to RD cells	IC50 (μg/mL)	SI	IC50 (μg/mL)	SI
KGS extract	1622.30	75.18	21.58	81.41	19.93
EA fraction	409.83	4.21	97.35	9.08	45.14
BuOH fraction	425.53	11.88	35.82	18.23	23.34
H2O fraction	>500	>100		>100
Eupafolin	355.87	0.44	808.80	1.66	214.38
Caffeic acid	274.72	23.87	11.51	35.51	7.74