Table 1

Role of SP and CGRP in allergic rhinitis:
 (i) promote vasodilation and plasma extravasation in nasal epithelium (nasal congestion)
 (ii) SP and CGRP act synergistically and potentiate each other in mast cell degranulation
  (early-phase allergic response) and plasma extravasation (nasal congestion)
 (iii) activate monocytes to release pro-inflammatory cytokines (early-phase allergic response)
 (iv) increase eosinophil accumulation in nasal mucosa during repeated allergen exposure
 (v) SP promotes production and release of NGF