Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 1

Research Article

Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation

Figure 1

Inhibitory effects of ellagic acid on platelet aggregation in washed human platelets. (a) Chemical structure of ellagic acid. (b)–(d) Washed platelets (  cells/mL) were preincubated with 20–120 μM ellagic acid or 0.5% DMSO; this was followed by the addition of 1 μg/mL collagen (○), 1  M U46619 (), 60  M arachidonic acid (□), or 0.05 IU/mL thrombin () to trigger platelet aggregation and an ATP-release reaction ((c), upper tracings). The data in (b) are presented as the means ± S.E.M. ( ). The profiles ((c) and (d)) are representative examples of 4 similar experiments.

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