Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae)
Table 1
Antimicrobial activity of Hyptis atrorubens hydromethanolic extracts (stems and leaves) against 29 microorganisms (no growth).
Strains
Stem extract (mg/mL)
Antibiotics
10
5
2.5
1.2
0.6
0.3
G
V
A
Gram-negative bacteria
Acinetobacter baumannii 9010
*
*
S
R
R
Acinetobacter baumannii 9011
*
*
*
R
R
R
Proteus mirabilis 11060
*
*
*
S
R
R
Proteus mirabilis 11061
*
*
S
R
R
Providencia stuartii 11038
*
S
R
S
Stenotrophomonas maltophilia
*
*
*
*
*
*
S
R
R
Pseudomonas aeruginosa 8131
*
*
*
S
R
R
Pseudomonas aeruginosa ATCC 27583
*
*
*
*
R
R
R
Gram-positive bacteria
Mycobacterium smegmatis 5003
*
*
*
*
*
S
S
S
Staphylococcus aureus 8146
*
*
*
*
S
S
S
Staphylococcus aureus 8147
*
*
*
*
S
S
S
Staphylococcus epidermidis 10282
*
*
*
*
*
*
S
S
S
Staphylococcus epidermidis 5001
*
*
*
*
*
*
S
S
S
Corynebacterium T25-17
*
*
*
*
*
S
S
S
Enterococcus sp. 8152
*
*
*
*
I
S
S
Enterococcus sp. 8153
*
*
*
*
R
S
S
Enterococcus faecalis C159-6
*
*
*
*
*
*
R
R
R
Staphylococcus lugdunensis T26A3
*
*
*
*
*
S
S
S
Staphylococcus warneri T12A12
*
*
*
*
*
S
R
S
Yeast
Candida krusei
*
*
*
*
*
—
—
—
Candida glabrata
*
—
—
—
Candida kefyr
*
*
—
—
—
Candida albicans
*
—
—
—
Candida parapsilosis
*
*
*
—
—
—
Dermatophyte
Microsporum canis
*
*
*
*
—
—
—
Trichophyton rubrum
*
*
*
*
*
—
—
—
Trichophyton mentagrophytes
*
*
*
*
*
—
—
—
Trichophyton soudanense
*
*
*
—
—
—
Trichophyton tonsurans
*
*
*
*
*
—
—
—
Microorganisms that were resistant to all extracts are not shown. Positive controls: MIC (g/mL) gentamicin (G) S: ≤4, R: >8; vancomycin (V) S: ≤4, R: >16; amoxicillin (A) S: ≤4, R: >16.
