Rosmarinic Acid and Its Methyl Ester as Antimicrobial Components of the Hydromethanolic Extract of Hyptis atrorubens Poit. (Lamiaceae)

Table 5

Antibacterial activities, indicated by Fractional Inhibitory Concentrations of combined compounds against selected microorganisms.

Bacteria	MIC (mg/mL)-FIC
	RA + MR	RA + IQ	RA + HS	MR + IQ	MR + HS	IQ + HS	RA + MR + IQ + HS
Staphylococcus epidermidis 5001	0.3-(I)	1.2-(AN)	0.3-(I)	0.3-(I)	0.3-(I)	2.50-(I)	0.15-(I)
Stenotrophomonas maltophilia	0.3-(I)	0.6-(I)	0.6-(I)	0.3-(I)	0.6-(I)	2.50-(A)	0.15-(I)
Enterococcus faecalis C159-6	0.15-(A)	0.6-(I)	0.3-(I)	0.15-(A)	0.3-(I)	1.25-(I)	0.07-(S)
Staphylococcus lugdunensis T26A3	0.6-(I)	0.3-(A)	0.6-(I)	0.15-(S)	0.6-(I)	2.50-(I)	0.3-(I)
Pseudomonas aeruginosa ATCC 27583	1.2-(I)	1.2-(I)	1.2-(A)	1.2-(I)	1.2-(I)	2.50-(I)	0.6-(I)
Corynebacterium T25-17	0.3-(S)	0.6-(A)	0.6-(A)	0.15-(S)	0.6-(A)	1.25-(I)	0.3-(A)
Mycobacterium smegmatis 5003	0.3-(A)	0.6-(A)	0.3-(S)	0.3-(A)	0.3-(A)	2.50-(I)	0.3-(A)
Staphylococcus warneri T12A12	0.15-(A)	0.6-(A)	0.3-(S)	0.3-(I)	0.3-(I)	2.50-(I)	0.3-(I)

Synergy (S, FIC ≤ 0.5), addition (A, 0.5 < FIC < 1), indifference (I, 1 < FIC < 4), and antagonism (AN, FIC ≥ 4) (ratio 1 : 1).