Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 609581, 13 pages
http://dx.doi.org/10.1155/2013/609581
Research Article

Phyllanthus Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NF B, and Hypoxia)

1Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Biotechnology Centre, Malaysia Agricultural Research and Development Institute (MARDI), 43400 Serdang, Malaysia
3Department of Trauma and Emergency Medicine, University Malaya Medical Centre, 46150 Kuala Lumpur, Malaysia

Received 30 January 2013; Revised 25 March 2013; Accepted 25 March 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Yin-Quan Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Rosenberg, Prudnikova, Gerashchenko, Grigorieva, and Kashuba, “Search for genes - Potential markers of aggressiveness and metastasis for human prostate cancer,” Biopolymers and Cell, vol. 29, no. 6, pp. 499–505, 2013. View at Publisher · View at Google Scholar
  • Nguyen Van Thanh, Phan Thi Thanh Huong, Nguyen Hoai Nam, Nguyen Xuan Cuong, Nguyen Phuong Thao, Bieke Dejaegher, Andrea Gordien, Yvan Vander Heyden, Joëlle Quetin-Leclercq, and Chau Van Minh, “A new flavone sulfonic acid from Phyllanthus urinaria,” Phytochemistry Letters, vol. 7, pp. 182–185, 2014. View at Publisher · View at Google Scholar
  • Masanori Hatashita, Masahiko Taniguchi, Kimiye Baba, Ken Koshiba, Takefumi Sato, Yutaka Jujo, Ryuta Suzuki, and Sachiko Hayashi, “Sinodielide A exerts thermosensitizing effects and induces apoptosis and G(2)/M cell cycle arrest in DU145 human prostate cancer cells via the Ras/Raf/MAPK and PI3K/Akt signaling pathways,” International Journal of Molecular Medicine, vol. 33, no. 2, pp. 406–414, 2014. View at Publisher · View at Google Scholar
  • Olga Krizanova, Iveta Steliarova, Lucia Csaderova, and Michal Pastorek, “Capsaicin induces apoptosis in PC12 cells through ER stress,” Oncology Reports, vol. 31, no. 2, pp. 581–588, 2014. View at Publisher · View at Google Scholar
  • Waranee Pradit, Siriwadee Chomdej, Korakot Nganvongpanit, and Siriwan Ongchai, “Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model,” In Vitro Cellular & Developmental Biology - Animal, 2014. View at Publisher · View at Google Scholar
  • Yao Li, Ming Yan, Zilu Wang, Yangyu Zheng, Junjun Li, Shu Ma, Genxia Liu, and Jinhua Yu, “17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway,” Stem Cell Research & Therapy, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Jisun Lee, Seul Lee, Sun-Lim Kim, Ji Won Choi, Jeong Yeon Seo, Doo Jin Choi, and Yong Il Park, “Corn silk maysin induces apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway,” Life Sciences, 2014. View at Publisher · View at Google Scholar
  • Yin-Quan Tang, Shamala Devi Sekaran, Indu Bala Jaganath, and Rishya Manikam, “Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes,” Nutrition and Cancer, vol. 67, no. 5, pp. 783–795, 2015. View at Publisher · View at Google Scholar
  • Dan Qu, Xiao-Man Xu, Meng Zhang, Ting-Shu Jiang, Yi Zhang, and Sheng-Qi Li, “Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling,” Molecular Medicine Reports, vol. 12, no. 1, pp. 1305–1313, 2015. View at Publisher · View at Google Scholar
  • Van Tang Nguyen, Quan Van Vuong, Michael C. Bowyer, Ian A. Van Altena, and Christopher J. Scarlett, “ Effects of Different Drying Methods on Bioactive Compound Yield and Antioxidant Capacity of Phyllanthus amarus ,” Drying Technology, pp. 150211123721006, 2015. View at Publisher · View at Google Scholar
  • Van Tang Nguyen, Hong Ngoc Thuy Pham, Michael C. Bowyer, Ian A. van Altena, and Christopher J. Scarlett, “Influence of solvents and novel extraction methods on bioactive compounds and antioxidant capacity of Phyllanthus amarus,” Chemical Papers, vol. 70, no. 5, pp. 556–566, 2016. View at Publisher · View at Google Scholar
  • Van T. Nguyen, Michael C. Bowyer, Ian A. Van Altena, and Christopher J. Scarlett, “Optimisation of microwave-assisted extraction from Phyllanthus amarus for phenolic compounds-enriched extracts and antioxidant capacity,” Chemical Papers, vol. 70, no. 4, pp. i–xiii, 2016. View at Publisher · View at Google Scholar
  • Xin Mao, Ling-Fang Wu, Hong-Ling Guo, Wen-Jing Chen, Ya-Ping Cui, Qi Qi, Shi Li, Wen-Yi Liang, Guang-Hui Yang, Yan-Yan Shao, Dan Zhu, Gai-Mei She, Yun You, and Lan-Zhen Zhang, “ The Genus Phyllanthus : An Ethnopharmacological, Phytochemical, and Pharmacological Review ,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–36, 2016. View at Publisher · View at Google Scholar
  • Van Tang Nguyen, Michael C. Bowyer, Ian A. Van Altena, and Christopher J. Scarlett, “ Microwave-assisted extraction as an advanced technique for optimization of saponin yield and antioxidant potential from Phyllanthus amarus ,” Separation Science and Technology, 2017. View at Publisher · View at Google Scholar
  • Surang Leelawat, and Kawin Leelawat, “Molecular mechanisms of cholangiocarcinoma cell inhibition by medicinal plants,” Oncology Letters, vol. 13, no. 2, pp. 961–966, 2017. View at Publisher · View at Google Scholar
  • Garima Shakya, Sangeetha Balasubramanian, Muddasarul Hoda, and Rukkumani Rajagopalan, “ Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract – an in vitro and in silico approach ,” Toxicology Mechanisms and Methods, pp. 1–14, 2017. View at Publisher · View at Google Scholar
  • Ji Won Choi, Jisun Lee, Seong Cheol Kim, SangGuan You, Chang Won Lee, Juhee Shin, and Yong Il Park, “Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death,” International Journal of Biological Macromolecules, 2018. View at Publisher · View at Google Scholar
  • Madamanchi Geethangili, and Shih-Torng Ding, “A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Mohamed Ali Seyed, “A Comprehensive Review on Phyllanthus derived Natural products as Potential Chemotherapeutic and Immunomodulators for a wide range of Human Diseases,” Biocatalysis and Agricultural Biotechnology, 2019. View at Publisher · View at Google Scholar