Protective Mechanisms of S. lycopersicum Aqueous Fraction (Nucleosides and Flavonoids) on Platelet Activation and Thrombus Formation: In Vitro, Ex Vivo and In Vivo Studies

Figure 5

Aqueous fraction inhibited platelet aggregation and ATP secretion. (a) saline and (b) aqueous fraction (1 mg/mL). Luciferin/luciferase reagent and then ADP 8 µM were added to PRP to induce aggregation and secretion, which were recorded in real time using the lumi-aggregometer. Each aggregation curve is representative of multiple traces obtained from three separate platelet donors. The graph depicts the mean ± SEM of 𝑛=3 experiments. **𝑃<0.01. PRP: platelet-rich plasma.

(a)

(b)