Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)

Table 1

Maximum plasma concentration (𝐶_max) reported in human subjects.

Compound	𝐶max (𝜇M)	Route of administration	Dose (mg)	Reference
Epicatechin	0.20	Oral	37	[7]
1,5-Dicaffeoylquinic acid	0.14	Oral	600	[23]
18β-Glycyrrhetinic acid	0.11–2.9^a	Oral	130–144 (glycyrrhizin)	[12, 24, 25]
Ursolic acid	7.4	i.v.	186	[13]

aAssuming plasma concentration of 18α- and 18β-glycyrrhetinic acid is about 1 : 3 as reported in [12].