Bees’ Honey Attenuation of Metanil-Yellow-Induced Hepatotoxicity in Rats

Table 1

Body weight and biochemical parameters of liver function tests of rat. Group 1, control; groups 2–4, rats treated with 50, 100, and 200 mg metanil yellow/kg body weight; groups 5–7, rat groups treated with 50, 100, and 200 mg metanil yellow/kg body weight plus 2.5 g/kg bees’ honey daily for 8 weeks, respectively.

	Group 1	Group 2	Group 3	Group 4	Group 5	Group 6	Group 7
Initial body weight, g	202 ± 15	200 ± 10	198 ± 14	205 ± 125	201 ± 16	200 ± 17	199 ± 16.5
Final body weight, g	253 ± 18	182 ± 12^a	175 ± 10^a	171 ± 14^a	235 ± 12^b	221 ± 11^c	239 ± 19^d
ALT, U/L	28.12 ± 1.12	95.32 ± 2.3^a	102.43 ± 3.2^a	110.12 ± 2.45^a	35.2 ± 1.3	35.5 ± 3.4	34.9 ± 4.2
AST, U/L	36.78 ± 1.5	95.78 ± 1.34^a	101.43 ± 2.5^a	120.45 ± 4.3^a	45.5 ± 5.3	51.3 ± 6.5	65.4 ± 5.2
ALP, U/L	194.34 ± 2.32	324.12 ± 16.8^a	398.34 ± 17.9^a	423 ± 23.5^a	220.5 ± 10.2^b	251 ± 15.6^c	245 ± 16.2^d
LDH, U/L	87.67 ± 2.12	150.56 ± 2.4^a	201.45 ± 4.6^a	234.76 ± 6.87^a	102 ± 4.2^b	124 ± 4.5^c	136 ± 6.3^d
GGT, U/L	72.36 ± 1.45	104.5 ± 2.43^a	132.87 ± 3.9^a	165.77 ± 5.4^a	89 ± 3.5	95.3 ± 3.4^c	99.5 ± 4.56^d
T. protein, mg%	8.13 ± 0.76	6.15 ± 1.27	5.97 ± 1.21	5.65 ± 1.54	6.8 ± 2.1	6.2 ± 2.3	7.1 ± 3.1
Albumin, mg%	5.54 ± 0.98	3.1 ± 0.54^a	2.86 ± 0.43^a	2.43 ± 0.56^a	4.95 ± 2.5^b	4.8 ± 1.2^c	4.75 ± 1.5^d
T. bilirubin, mg%	0.8 ± 0.05	1.3 ± 0.23^a	1.56 ± 0.56^a	2.5 ± 0.93^a	0.9 ± 0.01^b	0.91 ± 0.02^c	0.91 ± 0.02^d

All values were expressed as mean ± S.D. of triplicate tests (𝑛 = 10).
^a𝑃 < 0.05 versus group 1, ^b𝑃 < 0.05 versus group 2, ^c𝑃 < 0.05 versus group 3, ^d𝑃 < 0.05 versus group 4.