Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway

Figure 1

Effects of triptolide on severity of arthritis and arthritis progression in collagen-induced arthritis (CIA) mice. Mice were orally administered triptolide (Trip, 8, 16, and 32 μg/kg, resp.), methotrexate (MTX, 0.1 mg/kg), or vehicle for 21 days from the first day of the onset of the clinical symptoms of arthritis. At the end of the experiment, the arthritis index, arthritis incidence, the percentage of arthritic limbs, and changes in bodyweight were evaluated. Data are represented as the mean ± SD (𝑛=12)., ^#𝑃<0.05 in comparison with the normal control. ^∗𝑃<0.05,⁺𝑃<0.01, and ^∗𝑃<0.001 in comparison with the vehicle control. ^$𝑃<0.05 in comparison with methotrexate-treated CIA mice.

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