Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway
Micro-CT scan validates efficiency of triptolide in collagen-induced arthritis (CIA) mice. Mice were orally administered triptolide (Trip, 8, 16, and 32 μg/kg, resp.), methotrexate (MTX, 0.1 mg/kg), or vehicle for 21 days from the first day of the onset of the clinical symptoms of arthritis. At the end of the experiment, Micro-CT scan was performed to validate the efficiency of triptolide in CIA mice. (a) and (b), respectively, showed the three-dimensional reconstructed bones of ankle and knee joints in different groups. Compared with vehicle-treated and methotrexate-treated CIA mice, dose of 32 μg/(kg·day) triptolide markedly reduced the extent of joint destruction in triptolide-treated CIA mice.