Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo
Figure 8
Histological profiles of ventrum pedis skin, taken from control and CA-treated rats. Note that marked increases in ventrum pedis skin thickness due to edematous changes, with increases in inflammatory cell infiltrations, were detected by CA treatment, as compared with intact control, quite similar to those of dorsum pedis skin. However, these increases in skin thickness and inflammatory cell infiltrations were effectively inhibited by treatment with dexamethasone and two different dosages of PWS—0.3 and 1.0, respectively. In addition, in this experiment, treatment with dexamethasone and two different dosages of PWS also resulted in favorable preservation of mast cells from the degranulations induced by treatment with CA. (a) control, (b) CA, (c) CA and dexamethasone treated rats, (d) CA and test PWS 0.3 treated rats, (e) CA and test PWS 1.0 treated rats, CA: carrageenan, PWS: Pyungwi-san. The arrow indicated total thickness measured. Mast cells were stained with 1% toluidine blue. Scale bars: 40 μm.
