Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo
Figure 9
Immunohistochemistrical profiles of dorsum pedis skin, taken from control and CA-treated rats. Note that marked increases of COX-2, iNOS, and TNF-α positive inflammatory cells were detected in CA rat dorsum pedis skin, as compared with control, respectively. However, these increases of COX-2-, iNOS-, and TNF-α-immunoreactive cells were effectively inhibited by treatment with dexamethasone and two different dosages of PWS 0.3 and 1.0 g/kg, respectively. (a) control, (b) CA, (c) CA and dexamethasone treated rats, (d) CA and test PWS 0.3 treated rats, (e) CA and test PWS 1.0 treated rats. CA: carrageenan, PWS: Pyungwi-san, COX-2: cyclooxygenase-2, iNOS: inducible nitric oxide synthase, TNF-α: tumor necrosis factor-α. Immunoreactive cells were stained using ABC methods. Scale bars: 80 μm.
