Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo

Table 2

Changes on the histomorphometrical analysis of hind paw skins.

Index group	Skins
	Dorsum pedis skin		Ventrum pedis skin
	Thickness (epidermis to dermis; 𝜇m)	Infiltrated inflammatory cells (cells/mm^2 of dermis)	Thickness (epidermis to dermis; 𝜇m)	Infiltrated inflammatory cells (cells/mm^2 of dermis)
Control	536.68 ± 45.21	36.20 ± 14.92	304.13 ± 28.88	16.80 ± 8.64
CA	964.18 ± 102.77^a	261.60 ± 34.59^a	691.54 ± 47.19^a	998.20 ± 220.95^d
Dexamethasone	493.37 ± 59.22^c	63.20 ± 12.91^bc	419.19 ± 84.22^ac	359.60 ± 191.49^de
PWS 0.3	755.30 ± 81.18^ac	106.20 ± 16.75^ac	543.75 ± 63.14^ac	624.20 ± 82.36^de
PWS 1.0	579.82 ± 90.37^c	64.80 ± 12.38^bc	502.50 ± 25.23^ac	511.00 ± 86.23^de

Values are expressed as mean ± S.D. of five rat hind paws.
CA: carrageenan; PWS: Pyungwi-san.
^a𝑃<0.01 and ^b𝑃<0.05 as compared with intact control by LSD test.
^c𝑃<0.01 as compared with CA control by LSD test.
^d𝑃<0.01 as compared with intact control by MW test.
^e𝑃<0.01 as compared with CA by MW test.