Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo
Table 3
Changes in the numbers of mast cells, COX-2-, iNOS-, and TNF-α-immunoreactive cells in hind paw skins.
Cells
Control
CA
Dexamethasone
PWS 0.3 g/kg
PWS 1.0 g/kg
Dorsum pedis skin
Mast cells
49.20 ± 9.42
16.80 ± 6.57a
38.00 ± 8.17bc
31.60 ± 4.22ac
40.00 ± 6.20c
COX-2 + cells
17.20 ± 3.11
43.00 ± 9.97a
18.00 ± 1.58c
30.20 ± 6.76ac
22.60 ± 3.78c
iNOS + cells
10.20 ± 2.39
111.60 ± 40.34d
22.00 ± 3.87df
50.80 ± 14.31df
27.20 ± 8.17df
TNF- + cells
6.60 ± 2.07
95.80 ± 14.70a
31.40 ± 10.16ac
66.40 ± 11.22ac
32.40 ± 12.99ac
Ventrum pedis skin
Mast cells
44.60 ± 7.50
11.40 ± 2.30a
33.00 ± 7.91ac
25.80 ± 6.57ac
31.80 ± 4.21ac
COX-2 + cells
8.60 ± 1.95
43.80 ± 6.50a
15.60 ± 2.30bc
30.00 ± 7.45ac
15.20 ± 1.92bc
iNOS + cells
23.20 ± 6.06
135.80 ± 37.18d
32.20 ± 17.60f
65.40 ± 18.56df
36.60 ± 11.15ef
TNF- + cells
5.80 ± 1.64
118.00 ± 28.28d
28.80 ± 9.60df
74.00 ± 10.89df
30.40 ± 2.41df
Values are expressed as mean ± S.D. of five rat hind paws, cells/mm2 of dermis. CA: carrageenan; PWS: Pyungwi-san; COX-2: cyclooxygenase-2; iNOS: inducible nitric oxide synthase; TNF-: tumor necrosis factor-.
a and b as compared with intact control by LSD test.
c as compared with CA control by LSD test.
d and e as compared with intact control by MW test. as compared with CA control by MW test.