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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 630415, 13 pages
Research Article

Subamolide B Isolated from Medicinal Plant Cinnamomum subavenium Induces Cytotoxicity in Human Cutaneous Squamous Cell Carcinoma Cells through Mitochondrial and CHOP-Dependent Cell Death Pathways

1Institute of Biomedical Sciences, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 40227, Taiwan
2Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
3Department of Dermatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan
4Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11221, Taiwan
5Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan
6Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan
7School of Medical and Health Sciences, Fooyin University, Kaohsiung 83102, Taiwan
8Agricultural Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan
9Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan

Received 9 November 2012; Accepted 5 February 2013

Academic Editor: Shu-Ming Wang

Copyright © 2013 Shu-Yi Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Figure 1: Chemical structure of subamolide B.

Supplemental Figure 2: Kinectic analysis of component molecules involved in the extrinsic, intrinsic and ER stress cell death pathways upon subamolide B stimulation.

Supplemental Figure 3: SCC12 cells were resistant to imiquimod-induced cytotoxicity.

  1. Supplementary Figures