Magnolol Ameliorates Ligature-Induced Periodontitis in Rats and Osteoclastogenesis: In Vivo and In Vitro Study

Figure 7

Effect of magnolol on RANKL-induced bone resorption of mature osteoclasts in vitro. RAW 264.7 cells were incubated with various concentrations of magnolol (5–20 μM) in the presence of RANKL (50 ng/mL). (a) For the visualization of pits formation, the resorption area was analyzed by a microscope. (b) The percentage of resorption area caused by osteoclasts was measured. Data are expressed as the mean ± SD (𝑛=4). **𝑃<0.01, ***𝑃<0.001 versus RANKL-treated alone group.

(a)

(b)