Curcumin and Diabetes: A Systematic Review

Table 1

Diabetic animal models employed in studying the effect of curcumin on glycemia.

Animal	Induction of diabetes; (route and dose)	Curcumin; (route and dose)	Course of; treatment	Reference
Wistar rats	i.f. of STZ, 55 mg/kg·BW	Oral, 60 mg/kg·BW	14 days	[17, 18]
Wistar rats	i.p. of STZ, 55 mg/kg·BW; HFD	Oral, 150 mg/kg·BW	42 days	[19]
SD rats	HFD	Oral, 80 mg/kg·BW	15 and 60 days	[26]
SD rats	i.p. of STZ, 55 mg/kg·BW	Oral, 100 mg/kg·BW	28 days; 56 days	[21, 23]
Wistar rats	Injection of STZ, 45 mg/kg·BW	0.5% curcumin in diet	16 weeks	[27]
Wistar rats	i.p. of STZ, 55 mg/kg·BW	Oral, 300 mg/kg·BW	56 days	[20]
Wistar rats	i.p. of alloxan monohydrate; (150 mg/kg·BW)	Oral, 80 mg/kg·BW	21 days	[15]
Swiss mice	i.p. of STZ; (40 mg/kg·BW)	i.p., 10 mM	28 days	[32]
C57BL/6J mice	HFD	Oral, 50 mg/kg·BW	15 days	[33]
C57BL/6J mice: ob/ob mice	HFD	0.5% curcumin in diet	42 days	[29]
db/db mice	Not Applicable	0.02% curcumin in diet	42 days	[30]

i.f.: intrafemoral injection, i.p.: intraperitoneally injection.