Table 1: Diabetic animal models employed in studying the effect of curcumin on glycemia.

AnimalInduction of diabetes
(route and dose)
(route and dose)
Course of

Wistar ratsi.f. of STZ, 55 mg/kg·BWOral, 60 mg/kg·BW14 days[17, 18]
Wistar ratsi.p. of STZ, 55 mg/kg·BW; HFDOral, 150 mg/kg·BW42 days[19]
SD ratsHFDOral, 80 mg/kg·BW15 and 60 days [26]
SD ratsi.p. of STZ, 55 mg/kg·BW Oral, 100 mg/kg·BW28 days; 56 days[21, 23]
Wistar ratsInjection of STZ, 45 mg/kg·BW0.5% curcumin in diet16 weeks[27]
Wistar ratsi.p. of STZ, 55 mg/kg·BWOral, 300 mg/kg·BW56 days[20]
Wistar ratsi.p. of alloxan monohydrate
(150 mg/kg·BW)
Oral, 80 mg/kg·BW21 days[15]
Swiss micei.p. of STZ
(40 mg/kg·BW)
i.p., 10 mM28 days[32]
C57BL/6J mice HFDOral, 50 mg/kg·BW15 days[33]
C57BL/6J mice: ob/ob miceHFD0.5% curcumin in diet42 days[29]
db/db miceNot Applicable0.02% curcumin in diet42 days[30]

i.f.: intrafemoral injection, i.p.: intraperitoneally injection.