Table 2: The applications of curcuminoids in treating diabetes and its associated disorders.

CurcuminoidsStructuresAntidiabetic functionReference

NCDPCT/
EG2010/000008*
Decreasing lipid peroxides; attenuating mitochondria dysfunction [164]

Demethoxycurcumin (DMC) 636053.table.001a Induction of HO; elevating levels of glutamyl cysteine ligase and NAD(P)H:quinone oxidoreductase; inactivating pancreatic a-amylase [166, 167]
Bisdemethoxycurcumin (BDMC)636053.table.001b

Tetrahydrocurcumin (THC)636053.table.001cScavenging ROS; modulating hepatic metabolism enzyme and antioxidant enzyme; decreasing level of glycoprotein; normalizing erythrocyte membrane bounding enzyme and renal abnormalities. [14, 16, 35, 168178]

Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione636053.table.001dDeceasing ALP, LDH, TGA, FFA, and tissue phospholipids; elevating levels of SOD, CAT, and GPx. [179181]
Bis-o-hydroxycinnamoyl methaneScavenging ROS and protecting the pancreatic -cell

Bis(curcumino)oxovanadium complex636053.table.001eDecreasing blood glucose levels and serum lipids; restoring blood pressure and vascular reactivity[182]

C66636053.table.001fReducing production of TNF- and NO; inhibiting mRNA levels of IL-1 , TNF- , IL-6, IL-12, COX-2, and iNOS; inhibiting activation of JNK/NF- B signaling[183, 184]
B06636053.table.001g

Published patent pending, WO 2011/100984.