Review Article
Curcumin and Diabetes: A Systematic Review
Table 2
The applications of curcuminoids in treating diabetes and its associated disorders.
| Curcuminoids | Structures | Antidiabetic function | Reference |
| NCD | PCT/ EG2010/000008* | Decreasing lipid peroxides; attenuating mitochondria dysfunction | [164] |
| Demethoxycurcumin (DMC) | |
Induction of HO; elevating levels of glutamyl cysteine ligase and NAD(P)H:quinone oxidoreductase; inactivating pancreatic a-amylase |
[166, 167] | Bisdemethoxycurcumin (BDMC) | |
| Tetrahydrocurcumin (THC) | | Scavenging ROS; modulating hepatic metabolism enzyme and antioxidant enzyme; decreasing level of glycoprotein; normalizing erythrocyte membrane bounding enzyme and renal abnormalities. | [14, 16, 35, 168ā178] |
| Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione | | Deceasing ALP, LDH, TGA, FFA, and tissue phospholipids; elevating levels of SOD, CAT, and GPx. | [179ā181] | Bis-o-hydroxycinnamoyl methane | Scavenging ROS and protecting the pancreatic -cell |
| Bis(curcumino)oxovanadium complex | | Decreasing blood glucose levels and serum lipids; restoring blood pressure and vascular reactivity | [182] |
| C66 | | Reducing production of TNF- and NO; inhibiting mRNA levels of IL-1, TNF-, IL-6, IL-12, COX-2, and iNOS; inhibiting activation of JNK/NF-B signaling | [183, 184] | B06 | |
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Published patent pending, WO 2011/100984.
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