Ethanol Extracts of Fresh Davallia formosana (WL1101) Inhibit Osteoclast Differentiation by Suppressing RANKL-Induced Nuclear Factor-κB Activation
Figure 5
Effects of WL1101 on ovariectomy-induced bone loss in live rats. Distilled water or WL1101 (50 or 200 mg/kg/day) was orally administered to OVX rats via gastric intubation for 33 days (once/day). The body weight was recorded twice a week. On Day 29, the rats were anesthetized by isoflurane, and the right tibia was scanned and analyzed by μCT. (a) The body weight of OVX rats increased compared with sham-operated rats. Administration of WL1101 (50 or 200 mg/kg/day) had no effect on the OVX-induced increase of body weight. (b–f) The right tibia of each live rat was scanned by μCT on Day 29. Administration of WL1101 antagonized the decrease of bone mineral density (BMD) (b), bone volume (c), bone surface (d), and trabecular number (e). Administration of WL1101 exerted less effects on trabecular thickness (f). Each value represents mean ± S.E.M (). compared with sham-operated group. compared with the OVX-control group.
